brain concussion

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	194
interventional	134
Observational	57
Registry	3

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Behavioral	42
Other	28
Device	21
Drug|placebo	10
Procedure	6
Device|Other	5
Drug	4
Diagnostic Test	3
Dietary Supplement|placebo	3
Behavioral|Other	2
Drug|Other	2
Other|placebo	2
Behavioral|Device|placebo	1
Biological|placebo	1
Device|Other|Procedure	1
Device|placebo	1
Device|Procedure	1
Dietary Supplement|Other	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	91
Canada	20
Norway	4
Denmark	3
France	3
NA	3
Afghanistan	2
Finland	2
Canada|France|Israel	1
China	1
France|Monaco	1
Iraq	1
Malaysia	1
United States|Canada|New Zealand	1

Sites per Study

Site_count	Study_Count
1	105
2	13
3	7
4	2
5	2
6	1
7	1
8	1
11	1
18	1

Phase

Phase	Study_Count
N/A	112
Phase 2	10
Phase 1	6
Phase 1/Phase 2	3
Early Phase 1	1
Phase 3	1
Phase 4	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	16
2	92
3	11
4	10
5	2
NA	3

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.3	Phase.4
Min.	20	3.0000	16.00000	20.0000	20.00	NA	143
1st Qu.	20	45.7500	22.50000	110.0000	44.00	NA	143
Median	20	83.0000	32.00000	200.0000	55.00	NA	143
Mean	20	284.1786	35.83333	149.3333	70.90	NaN	143
3rd Qu.	20	200.0000	38.50000	214.0000	94.75	NA	143
Max.	20	4000.0000	75.00000	228.0000	180.00	NA	143

Trial Group Type

group_type	Group_Count
Experimental	143
Active Comparator	58
No Intervention	40
Placebo Comparator	25
Sham Comparator	11
Other	6
NA	3

Intervention Model

intervention_model	Study_Count
Parallel Assignment	101
Single Group Assignment	19
Crossover Assignment	7
Factorial Assignment	5
Sequential Assignment	1
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	88
Diagnostic	13
Prevention	11
Screening	8
Other	7
Basic Science	2
Health Services Research	2
Supportive Care	2
NA	1

Observational Studies

Studies by Country

Country	Study_Count
United States	41
Denmark	5
Ireland	2
Israel	2
Canada	1
China	1
France	1
France|Monaco	1
France|Spain	1
NA	1
Sweden	1

Sites per Study

Site_count	Study_Count
1	39
2	6
3	1
4	2
5	2
6	3
8	1
11	1
15	2

Enrollment Metrics

Measure	Observational
Min	3.000
1st Qu	63.000
Median	175.000
Mean	1813.263
3rd Qu	477.000
Max	45777.000

Observation Model

observational_model	Study_Count
Cohort	37
Case-Control	12
Case Control	4
Case-Only	3
Ecologic or Community	1

Time Perspective

time_perspective	Study_Count
Prospective	43
Cross-Sectional	8
Retrospective	6

Registries

Studies by Country

Country	Study_Count
NA	2
United States	1

Sites per Study

Site_count	Study_Count
1	3

Enrollment Metrics

Measure	Registries
Min	42.0000
1st Qu	201.0000
Median	360.0000
Mean	300.6667
3rd Qu	430.0000
Max	500.0000

Registry Model

observational_model	Study_Count
Case-Control	1
Case-Only	1
Cohort	1

Time Perspective

time_perspective	Study_Count
Prospective	2
Cross-Sectional	1

Follow-up

target_duration	Study_Count
1 Year	2
6 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04288167	Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents	https://ClinicalTrials.gov/show/NCT04288167	Recruiting	Medicortex Finland Oy	2021-02-28
NCT04044456	Combining Attention and Metacognitive Training to Improve Goal Directed Behavior in Veterans With TBI	https://ClinicalTrials.gov/show/NCT04044456	Recruiting	VA Office of Research and Development	2021-12-01
NCT03478059	Dual-task Assessment and Rehabilitation for Individuals With Residual Symptoms After mTBI	https://ClinicalTrials.gov/show/NCT03478059	Completed	Allina Health System	2019-06-30
NCT03819608	Neuromodulation and Neurorehabilitation for mTBI Plus PTSD	https://ClinicalTrials.gov/show/NCT03819608	Recruiting	Edward Hines Jr. VA Hospital	2022-03-31
NCT03306563	Rapid Biochemical Diagnostics of Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03306563	Completed	Medicortex Finland Oy	2019-02-28
NCT03237676	The Effect of Cognitive Rehabilitation Therapy in Improving Cognitive Function of Attention Following Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03237676	Recruiting	University of Malaya	2019-10-30
NCT03230656	Cognitive-Communication Screening and Early Therapy for Adults With Mild TBI	https://ClinicalTrials.gov/show/NCT03230656	Recruiting	Northern Arizona University	2020-12-31
NCT03221218	Enhanced Screening for Early Treatment Targets After MTBI	https://ClinicalTrials.gov/show/NCT03221218	Active, not recruiting	University of British Columbia	2019-10-30
NCT03217695	A Study on the Effect of Mindfulness-based Yoga on Youth With Persistent Concussion Symptoms	https://ClinicalTrials.gov/show/NCT03217695	Completed	Holland Bloorview Kids Rehabilitation Hospital	2016-10-07
NCT03215082	Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03215082	Recruiting	McGill University Health Centre/Research Institute of the McGill University Health Centre	2020-10-31
NCT03195738	Feasibility of a Cognitive Intervention for Youth Post Concussion	https://ClinicalTrials.gov/show/NCT03195738	Completed	Holland Bloorview Kids Rehabilitation Hospital	2016-03-30
NCT03180905	ImPACT Normative Extension	https://ClinicalTrials.gov/show/NCT03180905	Recruiting	ImPACT Applications, Inc.	2020-06-30
NCT03170856	The Effects of a Sub-maximal Exercise Program on Adolescents Who Sustained a Concussion	https://ClinicalTrials.gov/show/NCT03170856	Recruiting	Boston Children’s Hospital	2019-11-30
NCT03123822	To Compare the Effectiveness of 3 Different Types of Lens and Lens Coating in Eliminating Symptoms for Children With Prolonged Visual Symptoms Due to a Concussion.	https://ClinicalTrials.gov/show/NCT03123822	Recruiting	University of Alabama at Birmingham	2022-01-31
NCT03084211	Prescribed Light Exercise for ED Patients With MTBI	https://ClinicalTrials.gov/show/NCT03084211	Completed	Mount Sinai Hospital, Canada	2019-10-03
NCT03034720	Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth	https://ClinicalTrials.gov/show/NCT03034720	Completed	Seattle Children’s Hospital	2020-05-29
NCT03014492	Concussion Prevention in Soccer	https://ClinicalTrials.gov/show/NCT03014492	Completed	Children’s Hospital Medical Center, Cincinnati	2017-12-31
NCT02988596	Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial	https://ClinicalTrials.gov/show/NCT02988596	Completed	University of North Carolina, Chapel Hill	2019-08-31
NCT02969824	Post-acute Structured Exercise Following Sport Concussion	https://ClinicalTrials.gov/show/NCT02969824	Recruiting	University of Toronto	2021-01-31
NCT02959294	Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries	https://ClinicalTrials.gov/show/NCT02959294	Recruiting	Healeon Medical Inc	2023-11-30
NCT02959216	Aerobic Exercise for Concussion	https://ClinicalTrials.gov/show/NCT02959216	Active, not recruiting	Children’s Hospital of Philadelphia	2020-07-31
NCT02922569	Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI	https://ClinicalTrials.gov/show/NCT02922569	Active, not recruiting	Posit Science Corporation	2020-08-30
NCT02872480	Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants	https://ClinicalTrials.gov/show/NCT02872480	Completed	University of North Carolina, Chapel Hill	2017-02-28
NCT02868671	Acupuncture for Mild Traumatic Brain Injury With Post-traumatic Stress Disorder : A Functional Magnetic Resonance Imaging Study	https://ClinicalTrials.gov/show/NCT02868671	Recruiting	First Affiliated Hospital Xi’an Jiaotong University	2020-08-31
NCT02850926	Effect of Soccer Head Gear to Reduce Concussions	https://ClinicalTrials.gov/show/NCT02850926	Completed	University of Wisconsin, Madison	2018-06-30
NCT02844946	One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology	https://ClinicalTrials.gov/show/NCT02844946	Completed	VA Office of Research and Development	2018-09-03
NCT02819778	Study Assessing Evaluation of the Interest of Serum S100B Protein Determination in the Management of Pediatric Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02819778	Recruiting	University Hospital, Clermont-Ferrand	2020-04-30
NCT02812225	Non-blinded Data Collection Study of Concussion Using the BrainPulse(TM)	https://ClinicalTrials.gov/show/NCT02812225	Recruiting	Jan Medical, Inc.	2019-12-31
NCT02723344	Biological Signatures, Probiotic Among Those With mTBI and PTSD	https://ClinicalTrials.gov/show/NCT02723344	Completed	VA Office of Research and Development	2019-05-31
NCT02721537	Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes	https://ClinicalTrials.gov/show/NCT02721537	Recruiting	Mayo Clinic	2020-12-31
NCT02701842	ImPACT Online Clinical Study	https://ClinicalTrials.gov/show/NCT02701842	Completed	ImPACT Applications, Inc.	2016-06-30
NCT02690584	Metacognitive Therapy for Post-concussive Symptoms After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02690584	Recruiting	Norwegian University of Science and Technology	2020-11-30
NCT02634944	The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status	https://ClinicalTrials.gov/show/NCT02634944	Completed	University of Pittsburgh	2020-02-29
NCT02597504	Development of a Neurocognitive Screening Test	https://ClinicalTrials.gov/show/NCT02597504	Active, not recruiting	ImPACT Applications, Inc.	2019-09-30
NCT00857207	Metacognitive Training to Enhance Strategy Use in Blast-Related TBI	https://ClinicalTrials.gov/show/NCT00857207	Completed	VA Office of Research and Development	2019-12-23
NCT02556177	Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2	https://ClinicalTrials.gov/show/NCT02556177	Completed	GE Healthcare	2018-01-31
NCT03391583	Can Targeted Education Impact the Current Standard of Care in Patients With Mild Traumatic Brain Injury?	https://ClinicalTrials.gov/show/NCT03391583	Recruiting	St. Michael’s Hospital, Toronto	2019-12-17
NCT02455037	Evaluation of a Neck Strengthening Program to Reduce the Risk of Sport-related Concussion	https://ClinicalTrials.gov/show/NCT02455037	Completed	University of Michigan	2015-10-31
NCT02453958	Mild Traumatic Brain Injury Discrimination	https://ClinicalTrials.gov/show/NCT02453958	Completed	Empirical Technologies Corporation	2012-12-31
NCT02383472	LED Therapy for the Treatment of Concussive Brain Injury	https://ClinicalTrials.gov/show/NCT02383472	Completed	Boston Children’s Hospital	2016-05-31
NCT02374918	Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02374918	Completed	University of Arizona	2019-09-30
NCT02368366	Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI	https://ClinicalTrials.gov/show/NCT02368366	Completed	Children’s Hospital Medical Center, Cincinnati	2017-11-30
NCT02362347	Investigating Novel Treatments for Concussion: Impact of Compression Vest on Rehabilitation Outcomes	https://ClinicalTrials.gov/show/NCT02362347	Completed	Western University, Canada	2019-03-04
NCT02337101	Early Intervention Programme for Young Patients (Aged 15 - 30 Years) With Symptoms Following Concussion.	https://ClinicalTrials.gov/show/NCT02337101	Completed	University of Aarhus	2018-07-31
NCT02299128	Effectiveness of Early Physical Therapy Intervention for Patients With Dizziness After a Sports-Related Concussion	https://ClinicalTrials.gov/show/NCT02299128	Completed	Walsh University	2015-12-31
NCT02280304	Meditation in Veterans With PTSD and Mild TBI	https://ClinicalTrials.gov/show/NCT02280304	Completed	VA Office of Research and Development	2017-06-30
NCT02276079	The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02276079	Completed	University of Florida	2016-12-22
NCT02266329	Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin	https://ClinicalTrials.gov/show/NCT02266329	Recruiting	VA Office of Research and Development	2021-09-30
NCT02260570	Remediation of Impaired Self-Regulation in Patients With Mild TBI	https://ClinicalTrials.gov/show/NCT02260570	Active, not recruiting	VA Office of Research and Development	2020-06-29
NCT02114775	Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)	https://ClinicalTrials.gov/show/NCT02114775	Completed	The University of Texas Medical Branch, Galveston	2017-11-10
NCT02084329	Balance and Mild Traumatic Brain Injury: The Effect of a Weighted Compression Vest	https://ClinicalTrials.gov/show/NCT02084329	Recruiting	Lawson Health Research Institute	2021-04-30
NCT02069795	Speech Analysis as a Diagnostic Tool for Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02069795	Completed	Methodist Sports Medicine	2014-08-31
NCT01306968	Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT01306968	Completed	U.S. Army Medical Research and Development Command	2012-08-31
NCT02057081	Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI	https://ClinicalTrials.gov/show/NCT02057081	Completed	VA Office of Research and Development	2019-03-12
NCT04280965	Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT04280965	Recruiting	The University of Texas Health Science Center at San Antonio	2020-12-31
NCT01975857	Mind-Body Rehabilitative Program for Veterans With mTBI (Mild Traumatic Brain Injury)	https://ClinicalTrials.gov/show/NCT01975857	Completed	University of Utah	2018-02-28
NCT01947504	Early Intervention Following Mild TBI	https://ClinicalTrials.gov/show/NCT01947504	Completed	McGill University Health Centre/Research Institute of the McGill University Health Centre	2018-08-31
NCT01921179	Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI	https://ClinicalTrials.gov/show/NCT01921179	Completed	VA Office of Research and Development	2018-12-30
NCT01903525	DHA For The Treatment of Pediatric Concussion Related to Sports Injury	https://ClinicalTrials.gov/show/NCT01903525	Active, not recruiting	University of Texas Southwestern Medical Center	2020-06-30
NCT01860404	BCAA’s in Concussion	https://ClinicalTrials.gov/show/NCT01860404	Active, not recruiting	Children’s Hospital of Philadelphia	2022-01-31
NCT01815125	Ondansetron for Pediatric Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01815125	Completed	St. Justine’s Hospital	2014-02-28
NCT01814527	High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	https://ClinicalTrials.gov/show/NCT01814527	Completed	East Carolina University	2017-07-31
NCT01747811	Effects of Bright Light Therapy in Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01747811	Completed	University of Arizona	2013-12-31
NCT01728142	Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion	https://ClinicalTrials.gov/show/NCT01728142	Completed	Henry M. Jackson Foundation for the Advancement of Military Medicine	2014-08-31
NCT01728129	DANA Compared to MACE in Evaluation of Suspected Acute Concussion	https://ClinicalTrials.gov/show/NCT01728129	Completed	Henry M. Jackson Foundation for the Advancement of Military Medicine	2014-11-30
NCT01695577	Vestibular Rehabilitation and Balance Training After Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01695577	Completed	Oslo University Hospital	2016-08-30
NCT01640158	Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01640158	Completed	Posit Science Corporation	2017-03-02
NCT01614444	Acupressure and Stress Resilience	https://ClinicalTrials.gov/show/NCT01614444	Completed	VA Eastern Colorado Health Care System	2014-08-11
NCT01398566	Clinical Trial of a Rehabilitation Game - SuperBetter	https://ClinicalTrials.gov/show/NCT01398566	Completed	Ohio State University	2015-01-31
NCT01339806	The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01339806	Completed	Brooke Army Medical Center	2014-06-30
NCT04426188	" Acute Brain Changes After Repetitive Headers in Soccer and the Effects of a Protective Device "	https://ClinicalTrials.gov/show/NCT04426188	Recruiting	University Hospital, Bordeaux	2021-06-30
NCT04248218	Concussion Active Rehabilitation	https://ClinicalTrials.gov/show/NCT04248218	Enrolling by invitation	Children’s National Research Institute	2020-07-31
NCT04199247	Early Exercise to Improve Psychosocial Function After Pediatric Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT04199247	Recruiting	University of Colorado, Denver	2023-01-15
NCT04140084	Wiki Head CT Choice Study: Adaptation of US Two Decision Aids to a Québec Local Context	https://ClinicalTrials.gov/show/NCT04140084	Recruiting	Laval University	2020-02-15
NCT04122274	Comparing and Interactive Concussion Education Platform to Current Education Standards	https://ClinicalTrials.gov/show/NCT04122274	Enrolling by invitation	University of North Carolina, Chapel Hill	2020-12-31
NCT04121780	Growth Hormone Replacement Therapy for Retried Professional Football Players	https://ClinicalTrials.gov/show/NCT04121780	Recruiting	Center for Neurological Studies	2022-03-31
NCT04099329	One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles	https://ClinicalTrials.gov/show/NCT04099329	Recruiting	Seattle Children’s Hospital	2020-06-01
NCT04079907	Ketone Supplementation in Adolescents Post-Concussion	https://ClinicalTrials.gov/show/NCT04079907	Recruiting	University of Alabama at Birmingham	2020-10-17
NCT04068883	Controlled DTI Evaluations in High School Football and Female Soccer to Evaluate Efficacy of Jugular Compression Collar	https://ClinicalTrials.gov/show/NCT04068883	Active, not recruiting	Children’s Hospital Medical Center, Cincinnati	2019-06-30
NCT04043442	rTMS Target Identification for Functional Disability in AUD+mTBI	https://ClinicalTrials.gov/show/NCT04043442	Recruiting	VA Office of Research and Development	2023-07-01
NCT04036916	Sensorimotor Training for Injury Prevention in Collegiate Soccer Players II	https://ClinicalTrials.gov/show/NCT04036916	Completed	University of Mississippi Medical Center	2019-12-10
NCT03237468	Neck Strengthening Program for the Prevention or Mitigation of Sports Concussion	https://ClinicalTrials.gov/show/NCT03237468	Active, not recruiting	CentraCare	2020-06-30
NCT04012853	Remotely Supervised Transcranial Direct Current Stimulation for Persistent Post-traumatic Headache	https://ClinicalTrials.gov/show/NCT04012853	Recruiting	VA Office of Research and Development	2021-10-30
NCT04001192	Exercise in Patients With Post-Concussion Symptoms	https://ClinicalTrials.gov/show/NCT04001192	Recruiting	St. Olavs Hospital	2021-04-30
NCT03995173	Pilot rTMS for AUD+mTBI	https://ClinicalTrials.gov/show/NCT03995173	Recruiting	VA Office of Research and Development	2020-04-30
NCT03989999	Transcranial Ultrasonography for the Management of Patients With Mild TBI	https://ClinicalTrials.gov/show/NCT03989999	Recruiting	University Hospital, Grenoble	2022-05-31
NCT03974360	Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache	https://ClinicalTrials.gov/show/NCT03974360	Completed	Danish Headache Center	2019-12-31
NCT03972579	Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation	https://ClinicalTrials.gov/show/NCT03972579	Active, not recruiting	University of British Columbia	2021-02-15
NCT03952208	Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion	https://ClinicalTrials.gov/show/NCT03952208	Recruiting	Mayo Clinic	2021-12-31
NCT03917290	A Sports Injury Prevention Program to Reduce Subsequent Injuries After Concussion	https://ClinicalTrials.gov/show/NCT03917290	Recruiting	University of Colorado, Denver	2021-04-30
NCT03913975	Effects of Neuromuscular Training on EEG Adaptations in Young Athletes	https://ClinicalTrials.gov/show/NCT03913975	Completed	Children’s Hospital Medical Center, Cincinnati	2016-12-31
NCT03895450	Treating Persistent Post-concussion Symptoms With Exercise	https://ClinicalTrials.gov/show/NCT03895450	Active, not recruiting	University of Calgary	2021-09-30
NCT03889483	Neurophysiological Measurements Using the NeuroCatchâ„¢ Platform in Pediatric Concussion	https://ClinicalTrials.gov/show/NCT03889483	Recruiting	Alberta Children’s Hospital	2020-11-30
NCT03883451	Evaluation of Helmet Technology and Head Impact Exposure	https://ClinicalTrials.gov/show/NCT03883451	Active, not recruiting	Children’s Hospital Medical Center, Cincinnati	2020-12-10
NCT03865433	The Effect of a Sub-symptom Threshold Aerobic Exercise Program on Recovery in Concussed Athletes	https://ClinicalTrials.gov/show/NCT03865433	Recruiting	Rocky Mountain University of Health Professions	2020-07-01
NCT03811626	Efficacy of Multidimensional Management of Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03811626	Completed	Institut de Recherche sur la Moelle épinière et l’Encéphale	2013-06-30
NCT03799458	High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03799458	Recruiting	University of New Mexico	2021-09-30
NCT03786276	Virtual Reality- Working Memory Retraining	https://ClinicalTrials.gov/show/NCT03786276	Completed	University of California, San Francisco	2020-03-31
NCT03781076	Sleep After Adolescent Concussion	https://ClinicalTrials.gov/show/NCT03781076	Recruiting	Children’s Hospital Medical Center, Cincinnati	2019-10-31
NCT03759808	Treatment for Patients With Chronic Post-Concussion Symptoms	https://ClinicalTrials.gov/show/NCT03759808	Recruiting	University of California, Los Angeles	2021-02-01
NCT03759223	Enhanced Problem-Solving Training	https://ClinicalTrials.gov/show/NCT03759223	Recruiting	VA Office of Research and Development	2023-04-03
NCT03691363	Mobile Subthreshold Exercise Program for Concussion	https://ClinicalTrials.gov/show/NCT03691363	Completed	Seattle Children’s Hospital	2019-09-01
NCT03691272	rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head	https://ClinicalTrials.gov/show/NCT03691272	Completed	University of Calgary	2018-09-30
NCT03688984	Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03688984	Completed	University of Calgary	2018-01-17
NCT03677661	Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03677661	Recruiting	Laval University	2020-04-01
NCT03674398	Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology	https://ClinicalTrials.gov/show/NCT03674398	Completed	University of Illinois at Urbana-Champaign	2019-05-03
NCT03653195	Diagnosis of Sport-related Concussion Using Urine Metabolites	https://ClinicalTrials.gov/show/NCT03653195	Enrolling by invitation	University of Calgary	2019-05-01
NCT03608722	Video Games to Track Cognitive Health	https://ClinicalTrials.gov/show/NCT03608722	Active, not recruiting	BrainCheck, Inc.	2017-08-31
NCT03600324	Randomized Controlled Trial for Vestibular Treatment in Concussion	https://ClinicalTrials.gov/show/NCT03600324	Active, not recruiting	University of Pittsburgh	2022-12-31
NCT03598140	Sildenafil Treatment for Mild TBI	https://ClinicalTrials.gov/show/NCT03598140	Recruiting	University of Texas Southwestern Medical Center	2021-06-30
NCT03582579	Enhancing Brain Training With Virtual Reality	https://ClinicalTrials.gov/show/NCT03582579	Recruiting	University of Rochester	2021-03-31
NCT03564210	The Effect of Screen Time on Recovery From Concussion	https://ClinicalTrials.gov/show/NCT03564210	Recruiting	University of Massachusetts, Worcester	2020-07-01
NCT03539848	Diagnosis of mTBI in a Community Setting	https://ClinicalTrials.gov/show/NCT03539848	Recruiting	University of Miami	2021-06-30
NCT03529799	Disparity Driven Vergence in Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT03529799	Recruiting	University of Miami	2020-12-31
NCT03523507	fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population	https://ClinicalTrials.gov/show/NCT03523507	Recruiting	Henry M. Jackson Foundation for the Advancement of Military Medicine	2021-07-01
NCT03511339	Pro-2-Cool Device Clinical Study	https://ClinicalTrials.gov/show/NCT03511339	Recruiting	TecTraum Inc.	2020-01-31
NCT03479541	Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?	https://ClinicalTrials.gov/show/NCT03479541	Recruiting	Oregon Health and Science University	2021-09-30
NCT03417492	Cerebrovascular Reactivity in American Football Players	https://ClinicalTrials.gov/show/NCT03417492	Recruiting	University of Pennsylvania	2021-03-01
NCT03414242	Investigation of Neurocognitive Measures of Sport-Related Injury	https://ClinicalTrials.gov/show/NCT03414242	Enrolling by invitation	Mayo Clinic	2021-12-30
NCT01220713	Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT01220713	Completed	Virginia Commonwealth University	2013-07-31
NCT01101724	Effect of Early Rest on Recovery From Pediatric Concussion	https://ClinicalTrials.gov/show/NCT01101724	Completed	Medical College of Wisconsin	2011-12-31
NCT00893347	An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion	https://ClinicalTrials.gov/show/NCT00893347	Completed	University of British Columbia	2012-07-31
NCT00869154	Multidisciplinary Treatment in Patients With Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT00869154	Completed	Haukeland University Hospital	2013-03-31
NCT03869970	Active Injury Management (AIM) After Pediatric Concussion	https://ClinicalTrials.gov/show/NCT03869970	Recruiting	Medical College of Wisconsin	2022-03-31
NCT00822263	The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure	https://ClinicalTrials.gov/show/NCT00822263	Completed	Brooke Army Medical Center	2009-03-31
NCT03345550	OPTIMA-TBI Pilot Study	https://ClinicalTrials.gov/show/NCT03345550	Recruiting	University of Michigan	2020-07-27
NCT03244475	Transcranial Electrical Stimulation for mTBI	https://ClinicalTrials.gov/show/NCT03244475	Recruiting	VA Office of Research and Development	2021-09-30
NCT03213730	Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery	https://ClinicalTrials.gov/show/NCT03213730	Active, not recruiting	McGill University Health Centre/Research Institute of the McGill University Health Centre	2019-03-01
NCT03791515	Clinical Characteristics and Pathophysiology of Post-Traumatic Headache	https://ClinicalTrials.gov/show/NCT03791515	Completed	Danish Headache Center	2019-12-01
NCT00483444	Telephone Follow-Up on Outcome After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT00483444	Completed	University of Washington	2006-02-28
NCT00409058	Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI	https://ClinicalTrials.gov/show/NCT00409058	Completed	Children’s Hospital Medical Center, Cincinnati	2009-11-30
NCT00295074	The Effect of Mild Traumatic Brain Injury on Recovery From Injury	https://ClinicalTrials.gov/show/NCT00295074	Completed	University of Pittsburgh	NA
NCT00142090	Use of Salt-Water Solution to Improve Symptoms in Concussion	https://ClinicalTrials.gov/show/NCT00142090	Completed	Rady Children’s Hospital, San Diego	2005-12-31
NCT00004730	Magnesium Sulfate For Brain Injury	https://ClinicalTrials.gov/show/NCT00004730	Completed	University of Washington	2005-05-31

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03381638	Understanding Concussion/Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03381638	Completed	Blinktbi, Inc.	2018-04-17
NCT03319966	Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03319966	Recruiting	Hennepin Healthcare Research Institute	2019-06-30
NCT03313505	PROtein S100B for Mild Trauma of the HEad in Emergency Patients	https://ClinicalTrials.gov/show/NCT03313505	Recruiting	Centre Hospitalier Princesse Grace	2020-05-31
NCT03265912	Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Concussion Assessment	https://ClinicalTrials.gov/show/NCT03265912	Completed	ElMindA Ltd	2018-01-16
NCT03214432	Return to Work After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03214432	Completed	University of Copenhagen	2018-07-04
NCT03104244	Longitudinal Brain Health in Youth Tackle Football Players	https://ClinicalTrials.gov/show/NCT03104244	Recruiting	More Foundation	2020-08-31
NCT03011983	Neural Injury in Adolescents With Concussion	https://ClinicalTrials.gov/show/NCT03011983	Completed	Children’s Hospital of Philadelphia	2018-06-01
NCT02992795	Unblinded Data Collection Study of Concussion Using BrainPulse	https://ClinicalTrials.gov/show/NCT02992795	Completed	Jan Medical, Inc.	2017-05-31
NCT02992327	Biomarker Levels as A Predictor of Concussion Severity OUTcomes (BlacOut)	https://ClinicalTrials.gov/show/NCT02992327	Completed	HealthPartners Institute	2018-08-06
NCT02957461	Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes	https://ClinicalTrials.gov/show/NCT02957461	Completed	BrainScope Company, Inc.	2018-01-31
NCT02916108	Interhemispheric Anterior Delta Desynchronization in Children Who Present to the Emergency Department With Acute Concussion: A Proof of Concept Study	https://ClinicalTrials.gov/show/NCT02916108	Recruiting	Rambam Health Care Campus	2020-12-31
NCT02868684	Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study	https://ClinicalTrials.gov/show/NCT02868684	Recruiting	First Affiliated Hospital Xi’an Jiaotong University	2020-08-31
NCT02858544	Concussion in Motor Vehicle Accidents: The Concussion Identification Index	https://ClinicalTrials.gov/show/NCT02858544	Completed	Clionsky Neuro Systems Inc.	2016-06-30
NCT02776462	Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients	https://ClinicalTrials.gov/show/NCT02776462	Completed	Oculogica, Inc.	2017-11-16
NCT02771106	Neuroimaging and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02771106	Active, not recruiting	Hennepin Healthcare Research Institute	2020-04-30
NCT02754206	Cerebral Blood Flow Regulation and Concussions	https://ClinicalTrials.gov/show/NCT02754206	Recruiting	Southern Methodist University	2020-08-31
NCT02661633	Objective Brain Function Assessment of mTBI/Concussion in High School Athletes	https://ClinicalTrials.gov/show/NCT02661633	Completed	BrainScope Company, Inc.	2017-01-31
NCT02486003	Testing mTBI in Athletes	https://ClinicalTrials.gov/show/NCT02486003	Completed	University of Miami	2017-08-14
NCT02477943	Objective Brain Function Assessment of mTBI/Concussion in College Athletes	https://ClinicalTrials.gov/show/NCT02477943	Completed	BrainScope Company, Inc.	2017-02-20
NCT02354469	The Effects of Head Trauma on Collegiate Athletes	https://ClinicalTrials.gov/show/NCT02354469	Recruiting	Boston Children’s Hospital	2023-08-31
NCT02350894	Microstructural Changes in the Brain During Recovery After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02350894	Completed	University of Aarhus	2018-02-28
NCT02331901	Cerebral Microstructural Changes Following Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02331901	Completed	University of Aarhus	2016-09-30
NCT02317107	Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion	https://ClinicalTrials.gov/show/NCT02317107	Active, not recruiting	Boston Children’s Hospital	2020-01-01
NCT02171312	Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool	https://ClinicalTrials.gov/show/NCT02171312	Completed	Emory University	2015-09-30
NCT02069613	Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT02069613	Completed	Huntington Medical Research Institutes	2017-08-01
NCT01925963	Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL)	https://ClinicalTrials.gov/show/NCT01925963	Completed	Intermountain Health Care, Inc.	2016-01-06
NCT01922531	Defining Axonal Injury in Children With Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01922531	Completed	Children’s Hospital Medical Center, Cincinnati	2012-08-31
NCT01847040	Deployment Related Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT01847040	Completed	The Defense and Veterans Brain Injury Center	2013-08-31
NCT01832714	Assessment of Oculomotor, Vestibular and Reaction Time Response Following a Concussive Event	https://ClinicalTrials.gov/show/NCT01832714	Completed	Neuro Kinetics	2015-08-31
NCT01688869	Mild Traumatic Brain Injury Registry	https://ClinicalTrials.gov/show/NCT01688869	Completed	Atrium Health	2015-01-31
NCT01673464	A Prospective Study of Brain Network Activation (BNA) Changes in High School Athletes Following Concussion	https://ClinicalTrials.gov/show/NCT01673464	Completed	ElMindA Ltd	2014-04-30
NCT01661075	Quantification of Balance in Acutely Concussed Athletes	https://ClinicalTrials.gov/show/NCT01661075	Completed	Oregon Health and Science University	2016-06-30
NCT01625962	Brain Indices of Risk for Posttraumatic Stress Disorder (PTSD) After Mild Traumatic Brain Injury (mTBI)	https://ClinicalTrials.gov/show/NCT01625962	Completed	INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium	2015-03-31
NCT01535339	Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Sport Concussion Assessment - Test Stability and Effect of Concussion	https://ClinicalTrials.gov/show/NCT01535339	Completed	ElMindA Ltd	2015-12-31
NCT01377454	Balance and Mild Traumatic Brain Injury (TBI)	https://ClinicalTrials.gov/show/NCT01377454	Completed	Oregon Health and Science University	2012-08-31
NCT01334528	Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)	https://ClinicalTrials.gov/show/NCT01334528	Completed	VA Eastern Colorado Health Care System	2016-01-31
NCT04381767	EYE-SYNC Concussion Classification Study	https://ClinicalTrials.gov/show/NCT04381767	Completed	Sync-Think, Inc.	2020-03-23
NCT04109677	AIM CONTROL and SWECON - Handball The SWEdish CONcussion Study in Elite Handball	https://ClinicalTrials.gov/show/NCT04109677	Enrolling by invitation	Linkoeping University	2020-09-30
NCT04107844	Safe Return to Play After Concussion	https://ClinicalTrials.gov/show/NCT04107844	Recruiting	University College of Northern Denmark	2023-12-31
NCT04095377	Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.	https://ClinicalTrials.gov/show/NCT04095377	Active, not recruiting	QuantalX Neuroscience	2020-03-31
NCT04074486	Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC	https://ClinicalTrials.gov/show/NCT04074486	Recruiting	BrainScope Company, Inc.	2021-03-30
NCT04032509	A Study of Biomarkers of Mild Traumatic BRAIN Injury	https://ClinicalTrials.gov/show/NCT04032509	Recruiting	University Hospital, Grenoble	2020-11-30
NCT03963804	Objective Brain Function Assessment of mTBI/Concussion	https://ClinicalTrials.gov/show/NCT03963804	Completed	BrainScope Company, Inc.	2019-01-25
NCT03892356	Oculomotor Function Testing in Acute Concussion	https://ClinicalTrials.gov/show/NCT03892356	Recruiting	University Health Network, Toronto	2021-04-30
NCT03892291	Objective Dual-task Turning Measures for Return-to-duty Assessments	https://ClinicalTrials.gov/show/NCT03892291	Recruiting	Oregon Health and Science University	2022-09-30
NCT03777228	Integrated Eye Tracking and Neural Monitoring for Enhanced Assessment of Mild TBI: Primary Study	https://ClinicalTrials.gov/show/NCT03777228	Completed	Uniformed Services University of the Health Sciences	2017-03-15
NCT03678077	Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT03678077	Completed	University of Copenhagen	2019-03-13
NCT03624634	Assessment of the Effects of Concussion on Adolescent Rugby Union Players	https://ClinicalTrials.gov/show/NCT03624634	Recruiting	Sports Surgery Clinic, Santry, Dublin	2018-12-31
NCT03544372	Reliability of Self-reported Concussion History in Current Rugby Union Players	https://ClinicalTrials.gov/show/NCT03544372	Completed	University of Dublin, Trinity College	2017-12-20
NCT01044615	Advanced Imaging Tools in the Study of Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT01044615	Completed	Kettering Health Network	NA
NCT01021137	Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)	https://ClinicalTrials.gov/show/NCT01021137	Completed	VA Office of Research and Development	2016-12-30
NCT00822445	S100 Protein in Minor/Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT00822445	Completed	Assistance Publique - Hôpitaux de Paris	2010-05-31
NCT03671083	Validation of Brain Function Assessment Algorithm for mTBI/Concussion	https://ClinicalTrials.gov/show/NCT03671083	Completed	BrainScope Company, Inc.	2019-03-01
NCT02901821	Predicting Concussion Outcomes With Salivary miRNA	https://ClinicalTrials.gov/show/NCT02901821	Recruiting	Milton S. Hershey Medical Center	2021-12-31
NCT00724607	Brain Injury Outcomes (BIO) Study	https://ClinicalTrials.gov/show/NCT00724607	Recruiting	VA Office of Research and Development	2020-06-30
NCT00717301	S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT00717301	Completed	University of Rochester	2010-09-30
NCT00715949	Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population	https://ClinicalTrials.gov/show/NCT00715949	Completed	Children’s Hospital of Philadelphia	2007-12-31

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02977728	Olfactory Function in Patients With Acute Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02977728	Completed	Hôpital de Viege	2018-04-30
NCT02161172	Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury	https://ClinicalTrials.gov/show/NCT02161172	Completed	Shanghai 6th People’s Hospital	2014-04-30
NCT03966404	EyeBOX Concussion Study and Registry	https://ClinicalTrials.gov/show/NCT03966404	Recruiting	Oculogica, Inc.	2021-06-30